Paracetamol solubility in cosolvants Assignment Example | Topics and Well Written Essays - 250 words

Paracetamol solubility in cosolvants - naming ExampleBased on the experimental results, the molarity of paracetamol varies with percent alcohol in an exponential rove unlike the nearly linear relationships established by the same solute with propylene and glycerol. Such is an evidence of slump in polarity aside from the findings that for homologous n-alcohols, increase in the length of carbon chain and complexness in molecular structure, which is also true for ketones, contribute to the lowering of solubility. Thus, since alcohols like methanol, ethanol, and propanol possess wide miscibility with water and consist of polar molecules at the same time, greater extent of drug solubility shadow be expected for a paracetamol in an aqueous system with alcohol as the co-solvent. Due to this in high spirits level of solubility, the relationship between the concentrations of paracetamol and of alcohol becomes graphically non-linear whereas co-solvents other than alcohols bearing insigni ficant effect on solubility make a more linear variation with less steep slope upon prodigality of the drug